All Publications Why you should use it Login Thickening of the basement membrane Vitamin D Council The number of white patches What Is Ulcerative Colitis? Heart Disease The typical vitiligo macule is chalk white in color, has convex margins (as if the white areas were flowing into normally pigmented skin), is 5mm to 5cm or more in diameter, and is round, oval, or elongated in shape. Linear or artifactual macules represent the isomorphic or "Koebner" phenomenon, following repeated trauma or pressure on the elbows, knees, and bony prominences. The disease progresses by gradual enlargement of individual macules and the development of new white spots on various parts of the body. Teulings, H. E. et al. Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: a survey among 1307 patients and their partners. Br. J. Dermatol. 168, 162–171 (2013). Therapy at Home? Medscape Germany As an 18 year-old college freshman living in New York, I continue to search for more answers about the condition. However, I am no longer seeking a way to fix it. The past year has forced me to grow, along with Winnie Harlow and the 50 million bodies actively exhibiting the disorder. I now throw myself into new experiences as much as I can and choose to view my insecurity and discomfort with my body as only a segment of the self I used to cover up. I have been with my boyfriend for over a year and owe a good part of my self-assurance to the confidence he instills in me. He loves the marks. To others, my condition may be seen as an unfortunate abnormality, but it isn’t up to me to prove them wrong. It is up to me to accept myself, spotted or not. Coauthor(s) Hematology/Oncology Info & Metrics Cario-André, M., Pain, C., Gauthier, Y., Casoli, V. & Taoeb, A. In vivo and in vitro evidence of dermal fibroblasts influence on human epidermal pigmentation. Pigment Cell Res. 19, 434–442 (2006). 1.3.3 Translations Login CBSi Careers Healthy Living Healthy Abstract Bulut, H. et al. Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population. Genet. Mol. Res. 4, 4126–4132 (2011). MEDICAL ENCYCLOPEDIA Chief Editor Have a mural you want to show off? Send your photo to rstevenson@chicagotribune.com, and we’ll add it to the gallery. Type 2 Diabetes Warning Signs Colorectal Cancer Risks Wakao, S., Akashi, H., Kushida, Y. & Dezawa, M. Muse cells, newly found non-tumorigenic pluripotent stem cells, reside in human mesenchymal tissues. Pathol. Int. 64, 1–9 (2014). Rusfianti M, Wirohadidjodjo YW. Dermatosurgical techniques for repigmentation of vitiligo. Int J Dermatol. 2006 Apr. 45(4):411-7. [Medline]. . Starting to develop self-help for social anxiety associated with vitiligo: using clinical significance to measure the potential effectiveness of enhanced psychological self-help. Br J Dermatol. 2014;171(2):332–337pmid:24665869 How to Quit Smoking About UsContact Us How to treat and prevent scalp acne , Davinder Parsad5 73° Vitiligo is a chronic, acquired depigmenting condition of the skin, and sometimes of the mucosa, that results in the selective loss of melanocytes.1 Vitiligo has been reported since ancient times and a description of it exists in the Latin medical classic De Medicina of Celsus during the second century.2,3 The name might come from the Latin “vitium,” meaning defect or blemish.4 Although vitiligo is not a rare disease, it has been until recently an orphan disease in terms of drug development and a neglected one in the field of dermatology. Moreover, patients often complain that physicians are unaware of treatment options and that most of these physicians consider vitiligo as a “cosmetic disease.”5 Despite the lack of demonstrative physical symptoms accompanying the disease as compared with other common chronic dermatological disorders, such as eczema and psoriasis, vitiligo causes emotional distress and impairs patient and parental quality of life in childhood. What Is the Prognosis of Vitiligo? Skin Conditions Resources Share This Article: Copy de Moura, M. B., Uppala, R., Zhang, Y., Van Houten, B. & Goetzman, E. S. Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells. PLoS ONE 9, e106028 (2014). print Allergy Frontiers in Medicine Nieuweboer-Krobotova L, et al Skin camouflage[edit] Cirino PV, Slideshow Tips to Help You Stop Wasting Time ✔ Health Videos Agents 2014 Fall Meeting Nutrition / Diet Foundation Levels of Giving Blogs Learn about skin cancer Shah, R., Hunt, J., Webb, T. L. & Thompson, A. R. Starting to develop self-help for social anxiety associated with vitiligo: using clinical significance to measure the potential effectiveness of enhanced psychological self-help. Br. J. Derm. 171, 332–337 (2014). Recommended related news Lister Hill National Center for Biomedical Communications Vitiligo Can Increase Your Risk for Other Autoimmune Diseases Scientific editing Deleo V, 29. CBS Interactive Learn more about PUVA therapy for vitiligo » Volunteer opportunities Bacterial Skin Diseases Cart Miniati A, et al Pityrosporum orbiculare, the yeast that causes tinea versicolor, is present in small numbers on normal skin; regular washing rids the skin of dead skin cells as well as excess yeast. But it can grow in great amounts - during the summer months when humidity sky-rockets or when a person's immune system is weakened - and interfere with the normal pigmentation of the skin; resulting in unsightly spots in both light and dark colors. continuously reappear Miniati A, et al More Related Topics skin that has folds, such as the elbows, knees, or groin Copyright © 2018 SkinVision - Skin cancer melanoma detection app. All Rights Reserved. Contagious skin diseases 150. Drawbacks: These medicines have possible side effects, so patients must be carefully monitored. A possible serious side effect of using of a topical corticosteroid for a year or longer is skin atrophy. This means the skin becomes paper thin, very dry, and fragile. 2013 Annual Meeting In noninherited lesions, which are the most common differential diagnoses in children with vitiligo, pityriasis versicolor (Fig 4B) and postinflammatory hypomelanoses (hypopigmentation) should be ruled out. A Wood lamp can be used to highlight lesions of vitiligo for confirmation distinguishing vitiligo from pityriasis alba (Fig 4C); on the other hand, one of the neoplastic hypomelanoses to exclude is mycosis fungoides (Fig 4D), and that may highlight on Wood lamp examination.45,46 Therefore, biopsy may be required in atypical cases and where mycosis fungoides is suspected; in that setting, T cell gene rearrangement studies on the biopsy may be helpful. Oxidant-antioxidant mechanisms: An intermediate or metabolic product of melanin synthesis causes melanocyte destruction. Make a difference Manage Diabetes in 10 Minutes The basic types of repigmentation surgery include the following [6, 7] : Vitiligo Research Foundation PsoriasisSee What It Looks Like and How to Treat It Experts don't know exactly what causes vitiligo, but they do have theories. Some think it's an and that the immune system is mistakenly attacking healthy melanocytes. Others think it's genetic. Antoniou C, Sharquie, K. E., Noaimi, A. A., & Salmo, H. M. (2013, July). Pityriasis alba versus vitiligo. Journal of the Saudi Society of Dermatology & Dermatologic Surgery, 17(2), 51–54. Retrieved from http://www.sciencedirect.com/science/article/pii/S2210836X13000213 American Vitiligo Research Foundation My WebMD Pages . Segmental vitiligo may not be associated with risk of autoimmune thyroiditis. Skinmed. 2011;9(5):329–330, author reply 330pmid:22165052 United States. National Institute of Arthritis and Musculoskeletal and Skin Diseases. "Fast Facts About Vitiligo." Nov. 1, 2014. . 109. This takes between one and two years, depending on the location of the body being treated. However, in most cases the white spots reappear at the same location, often within just one year after stopping the treatments. This recurrence can be just as devastating as when the white patches first appeared. Lila and Murray Gruber Cancer Research Award and Lectureship backs of the knees Generally, the diagnosis can be accurately made during a physical examination without the benefit of any further laboratory support. Follow us A dermatologist can usually tell if someone has vitiligo just by looking for the telltale white patches. On people with fair skin, a special tool called a Woods lamp might be used. This lamp uses ultraviolet light in a dark room to illuminate areas of damaged skin that would otherwise be hard to see with the naked eye. Academy meeting Join 160. 1-877-Yale-MDs “Vitiligo”. Mayo Clinic Foundation. Retrieved Mar 19, 2015. http://www.mayoclinic.org/diseases-conditions/vitiligo/basics/definition/con-20032007. What Cholesterol Levels Mean van Geel N, Speeckaert R, Taieb A, Picardo M, Böhm M, Gawkrodger DJ, et al. Koebner's phenomenon in vitiligo: European position paper. Pigment Cell Melanoma Res. 2011 Jun. 24 (3):564-73. [Medline]. Health Solutions Inside Mercola.com Learning/CME Eisinger M, CBSNews.com Main Dishes Related Doctors By Jennifer Huizen Characters remaining: F/bookTwitterGoogleEmail Depigmentation References . Epidemiologic study of dermatologic disorders among children in South Sinai, Egypt. Int J Dermatol. 2012;51(10):1180–1185pmid:22834561 Bastonini, E., Kovacs, D., Ottaviani, M., Dell'Anna, M. L. & Picardo, M. in XXII International Pigment Cell Conference (IPCC) http://www.ifpcs.org/ipcc2014/docs/IPCC%202014%20-%20Pigment%20Cell%20Melanoma%20Research%20Journal.pdf (2014). psoralens and UVA Sign up for the My MedlinePlus newsletter What's this? 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