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[PubMed] Are You a Mosquito Magnet? The best of the best. The topical wrinkle reducer is one the best studied ingredients for fighting signs of aging, but applying too much or applying it too frequently may lead to skin irritation and dryness. “During the first two to four weeks of using retinol, the skin cells undergo a process called retinization, during which skin cells adjust to the retinol,” explains Dr. Zeichner. “You must be cautious during this period because the skin can easily become dried out.” He recommends applying one pea-sized amount of retinol to cover the whole face and apply it every other night. In addition, you can apply a moisturizer, such as RoC Retinol Correxion Deep Wrinkle Night Cream, to the face before the retinol to keep the skin hydrated and primed to receive the retinol. These are the 7 anti-aging secrets that could add years to your life. 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