Fashion Brands TenMarks.com Activate Online Access Demographic characteristics of the groups of patients. Scopus (178)
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Diseases of children (pediatrics) The epidermal barrier dysfunction hypothesis suggests that AD patients develop AD as a result of skin barrier defects that allow for the entry of antigens, resulting in the production of inflammatory cytokines. Some authors question whether such antigens can also be absorbed from the gut (eg, from food) and/or the lungs (eg, from house dust mites). Xerosis and ichthyosis are known to be associated signs in many AD patients. Clinically, 37-50% of people with ichthyosis vulgaris have atopic disease and up to 37% of people with AD have clinical evidence of ichthyosis vulgaris. Mutations in the gene encoding filaggrin, a key epidermal barrier protein, cause ichthyosis vulgaris and are the strongest known genetic risk factors for the development of AD. [18, 19]
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More from WebMD Procedures A-Z Homey B Allergic march Eczema Resource Center How do dermatologists treat neurodermatitis? Signs and symptoms of neurodermatitis include:
The inflamed area can be treated with topical creams, such as corticosteroid, antihistamine, capsaicin cream or doxepin cream. Patient and Visitor Guide Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel
To the products EClinicalMedicine Dark patches on the skin Tupker RA Neurodermatitis is a skin condition that’s also known as lichen simplex chronicus. It causes patches of itchy skin that lead to scratching, which makes you feel even itchier. The condition isn’t contagious. It may be due to something that irritates your skin, like a bug bite or tight clothes that trigger the itch-scratch cycle.
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J Allergy Clin Immunol. 1999; 104: 1066-1070 Visit ScienceDirect to see if you have access via your institution.
Prostatitis Wasp venom allergy Faux JA Kubo A, Nagao K, Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest. 2012 Feb 1. 122(2):440-7. [Medline]. [Full Text].
Colorado Cleansers The report looks at three important factors: Advanced Middel P Education and courses on the subject "Neurodermatitis" (in German)
Add to favorites Neurodermatitis is a chronic, severely pruritic disorder characterized by 1 or more lichenified plaques in which the skin is thickened and there are accentuated skin markings. It affects adults, predominantly from ages 30 to 50 years. Women are affected more commonly than men. It may lead to demoralization, sleep disturbances, anxiety, depression, obsessive‐compulsive disorder, and distress through its impact on the patient's well‐being (Burgin, 2008). If the patient suffers from psychologic problems, the lesions are more likely to be persistent (Stander and Metze, 2009). Whether emotional factors are secondary to the primary dermatologic disease or they are primary and causative (altering perception of itch) is unclear. It has been postulated that neurotransmitters that affect mood, such as dopamine, serotonin, and opioid peptides, modulate perception of itch via descending spinal pathways (Burgin, 2008).
Email Alerts Yale Liu, Tian Li, Jingang An, Weihui Zeng and Shengxiang Xiao, Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients, Health and Quality of Life Outcomes, 14, 1, (2016).
Cosmetic treatments In conclusion, neurodermatits moderately affected the QoL of the patients. People should pay more attention to the chronic disease, although it is not life-threatening. There are two limitations in this study: we were unable to compare QoL of patients before and after treatment, which could be incorporated in the planning of future studies. Another comment is related to the questionnaire itself, part of patients worried about the impact of diet on disease which does not exist in DLQI because of the different culture background.
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Drugs A-Z Seborrheic Dermatitis in Children Flexural involvement in childhood atopic dermatitis. Vidal’s disease has acanthosis, papillomatosis with the pronounced hyperkeratosis. In the papillary dermal layer and in its upper part focal, predominantly perivascular infiltrates, composed of lymphocytes with an admixture of fibroblasts and also fibrosis, are detected. Sometimes the picture resembles psoriasis. In some cases, there are areas of spongiosis and an intracellular edema that resembles contact dermatitis. Proliferating cells are rather large, in case of the application of usual methods of painting they can be mistakenly determined as atypical ones, observed in the presence of fungal mycosis. In such cases, clinical data help to do a correct diagnosis.
Poor Air Quality Feedback In AD, transepidermal water loss is increased. Whether the primary immune dysregulation causes secondary epithelial barrier breakdown or primary epithelial barrier breakdown causes secondary immune dysregulation that results in disease remains unknown. However, given the fact that filaggrin is critical for epithelial integrity, it is now thought that loss of filaggrin function leads to increased transepidermal penetration of environmental allergens, increasing inflammation and sensitivity and potentially leading to the atopic march. 
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