eczema treatment | lichen planus and hair loss

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Lichen planus (LP) is an inflammatory skin condition with characteristic clinical and histopathological findings. Classic LP typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist, including oral, nail, linear, annular, atrophic, hypertrophic, inverse, eruptive, bullous, ulcerative, lichen planus pigmentosus, lichen planopilaris, vulvovaginal, actinic, lichen planus-lupus erythematosus overlap syndrome, and lichen planus pemphigoides. Clinical presentation of the rarer variant lesions may be largely dissimilar to classic LP and therefore difficult to diagnose based solely on clinical examination. However, histopathological examination of LP and LP-variant lesions reveal similar features, aiding in the proper diagnosis of the disease. Management of LP and LP variants aims to control symptoms and to decrease time from onset to resolution; it often involves topical corticosteroids, but varies depending on the severity and location of the lesion. The literature contains an array of reports on the variations in presentation and successful management of LP and its variants. A familiarity with LP and its variants is important in achieving timely recognition and management of the disease.
Critical Care Medicine Two-dimensional polyacrylamide gel electrophoresis images of the pooled salivary proteins from the oral lichen planus (OLP) group (a) and pooled healthy control group (b). a, b The identification of 31 protein spots that either demonstrated a ≥ 1.5-fold difference in abundance or were found exclusively in one group (OLP or healthy control) is demonstrated
+ Skin biopsy Rilievi ipercheratosici e rigidi (palmo)    Saurabh Joshi, MDS It’s not known what causes oral lichen planus. However, T lymphocytes — certain white blood cells involved in inflammation — appear to be activated in oral lichen planus. Although it could indicate an immune disorder, more research is needed to determine the exact cause.
PICMED Grant Pain or discomfort Formats: WebMD Medical Reference Reviewed by Michael Friedman, DDS on January 17, 2018 + Scorbut, avitaminosis C
Figure 5. Tollfree: (800) 411-1222 Excellence in Dermatology™ Sometimes, creams or ointments may contain drugs that reduce the immune response.
Alpha-tocoferol (vitamin E) was also an effective antioxidant at high levels of oxygen, protecting cellular membranes from lipidic peroxidation. It can be used to reduce the size of lichen planus lesions.29
Living Healthy + Eczema atopicum (dermatitis atopica) Providers Mohs Fellowship Report Clinical Assistant Professor
Current Award and Grant Recipients Genital LP can be truly one of the most difficult areas to treat. High potency topicals and ILK are my first choice with topical tacrolimus and pimecrolimus my second-line agents. The physician should be aware that this is a condition with psycho-social-sexual connotations and referral to a gynecologist and psychiatric specialist may be helpful in certain cases. One should inquire, “How is this affecting your sex life? How does this affect you on a day-to-day basis?” Patients will not offer this information up without being asked.
DOI: Media contacts 10 squamous cell carcinoma 10.6 + Halo nevus Skin Problems and Treatments Resources + Superficial thrombosis
2001 http://www.medscape.com/pages/editorial/resourcecenters/public/anthrax/rc-anthrax.ov Resource Center There is no known cure for skin lichen planus, but treatment is often effective in relieving itching and improving the appearance of the rash until it goes away. Since every case of lichen planus is different, no one treatment does the job. Topical corticosteroids are very useful. Antihistamines may be prescribed to relieve itching. Extensive cases may require the use of oral corticosteroid (cortisone, prednisone) for a number of weeks. This usually shortens the duration of the outbreak. For severe cases powerful treatments include photo chemotherapy light treatment (PUVA), the retinoids drugs (Soriatane and Accutane), cyclosporine and hydroxychloroquine.
References Notes Oral lichen planus (OLP) is a chronic autoimmune, mucocutaneous disease that affects the oral mucosa as well as the skin, genital mucosa, scalp, and nails. It is one of the most common dermatological diseases presenting in the oral cavity. An immune-mediated pathogenesis is recognized in lichen planus, although the exact etiology is unknown. The disease most commonly affects middle-aged females. It is infrequently found in children, with a prevalence of about 0.03%, and reports of this are scarce in the literature. The erosive and atrophic forms of OLP are less common, yet they are more likely to cause symptoms. OLP is the target of much controversy, especially in relation to its potential for malignancy. Thus, it is important for clinicians to maintain a high index of suspicion for all intraoral lichenoid lesions. Periodic follow-up of all patients with OLP is recommended. In view of the above, the authors highlight a case of gingival erosive lichen planus affecting a 17-year-old adolescent without concomitant cutaneous lesions, with special emphasis on clinical and microscopic characteristics of the condition and management with retinoids and steroid therapy.
antimalarials Intense itching may occur, especially at night. View all multimedia Condition Distinguishing features Diagnostic method Treatment Differential diagnosis[edit]
Abstract 10.1007/s00105-017-4115-0 There are also variations of the condition more common in the Middle East, Asia, Africa, and Latin America.
23.1 Merck Manuals The datasets generated during the current study are available from the corresponding author on reasonable request. © 2018 MedPage Today, LLC. All rights reserved.
Lichen Planus, Oral 73 Some Types of Lichen Planus Teledermatology Hematology/Oncology Enzyme-linked immunosorbent assay Rhodus NL, Cheng B, Myers S, Bowles W, Ho V, Ondrey F. A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol. 2005 Mar. 114(3):278-83. [Medline].
+ Alopecia areata Same-Day Appointments Lichen planus – British Association of Dermatologists Travel and Lodging Er bestaan momenteel tegenstrijdige berichten over de relatie van lichen planus in de mond en huidkanker. Tot nu toe zijn de bewijzen hiervoor echter niet overtuigend zodat we ervan moeten uitgaan dat lichen planus in de mond goedaardig is en blijft.
Srinivasan M, Kodumudi KN, Zunt SL. Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. Clin Immunol. 2008;126(1):31–7.View ArticlePubMedGoogle Scholar
Other mucosal sites Description Category Score Evidence PubmedIds Decorso della malattia Talk to your doctor about changing medications that may be to blame.
Meet the Staff More Related Topics The onset of lichen planus can be sudden or gradual. The first attack may last for weeks or months, and recurrences may happen for years. The bumps at first are 2 mm-4 mm in diameter, with angular borders and a violet color. An excess of pigment (hyperpigmentation) may develop in the affected skin as the lesions persist. If lichen planus involves the scalp, it can permanently damage the hair follicles, producing a patch of bald skin called lichen planopilaris. If lichen planus involves the finger or toenails, scarring often occurs, producing permanently malformed nails. Ulcerative lichen planus may occur if oral or vaginal lining tissue (mucosa) are involved.
+ Generalized pustular psoriasis of Zumbusch R/ Betnelan mondpasta 0.025% of 0.1%, Dermovate mondzalf of Clobetasol mondspoeling. Zie voorbeelden receptuur hieronder.
Digital learning series + Amputation stump Altered immune response with T cell activation Pagination Another case: Lichen planus, developed, HE 40x (3667)
Topical calcineurin inhibitor (tacrolimus 0.03% or 0.1% ointment). Must counsel patients not to overapply CO2 laser ablation  Low-dose excimer laser  
+ Disorders of the sweat glands Wickham’s striae Medicines that calm down the immune system (in severe cases)
Drug Basics & Safety 6.32 13.53 (7.87, 27.36) Classical violaceous polygonal plaques
 R & E Shengyuan L, Songpo Y, Wen W, Wenjing T, Haitao Z, Binyou W. Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol. 2009 Sep. 145(9):1040-7. [Medline].
Intercellular Adhesion Molecule 1 Protein Coding 28.98 MS Care 360 Usatine, R. P. & Tinitigan, M. (2011, July). Diagnosis and treatment of lichen planus. American Family Physician, 1, 84(1), 53-60. Retrieved from http://www.aafp.org/afp/2011/0701/p53.html
Skin involvement: The usual skin involvement with lichen planus consists of flat-topped lilac or violet to brown spots a few millimeters in diameter on the skin. These spots tend to be located on the inner wrists, forearms, the lower legs just above the ankles, and the lower part of the back.
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17 Replies to “eczema treatment | lichen planus and hair loss”

  1. Victor D. Newcomer Endowed Lectureship
    Questions to ask your doctor
    Blisters that may break to form scabs or crusts
    Scleroderma
    Direct immunofluorescence study reveals globular deposits of immunoglobulin M (IgM) and complement mixed with apoptotic keratinocytes. No imaging studies are necessary.
    avoiding scratching
    Are located on the sides of the tongue, inside of the cheek, or on the gums

  2. It’s also important to enjoy a diet rich in fruit and vegetables. If you smoke, quit. Don’t drink large amounts of alcohol. See your doctor regularly to look for any changes in your mouth.
    7. James WD, Berger T, Elston D. Andrews’ Diseases of the Skin: Clinical Dermatology. Philadelphia, PA: Elsevier Health Sciences; 2015.
    All Subjects All Subjects
    Scalp
    + Acroangiodermatitis
    Classical violaceous polygonal plaques

  3. + Perifollicular fibroma
    Treatment Ladder for Lichen Planopilaris
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  4. Metallic taste in the mouth
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    Use of Double Layer of Acellular Dermal Matrix and Modified Tunnel Technique to Treat Multiple Adjacent Gingival Recession Defects
    10. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):164–178.
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  5. Omal P, Jacob V, Prathap A, Thomas NG (2012) Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in southern India. Indian J Dermatol 57:107–109CrossRefPubMedPubMedCentralGoogle Scholar
    Cytokeratins are proteins expressed in epithelial cells. It has been used for the markers of epithelial cell differentiation and have been used for determining tumor origin and epithelial cell typing [77].
    Oral lichenoid drug eruption
    + Diffuse scleroderma
    Intralesional steroid injections
    Epidemiology: : rare disease; more common in women (postmenopausal)
    Other possible triggers include medicines like painkillers, high blood pressure treatments, diabetes drugs, and malaria medications.
    Open sores
    Low molecular weight heparin

  6. LinkOut – more resources
    + Incontinentia pigmenti
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    43 MedlinePlus
    Sugerman PB, Savage NW, Zhou X, Walsh LJ, Bigby M. Oral lichen planus. Clin Dermatol. 2000 Sep-Oct. 18(5):533-9. [Medline].
    2. Silverman S, Gorsky M, Lozada-Nur F. A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association. Oral Surg Oral Med Oral Pathol. 1985;60:30–4.
    Skin sores are another symptom of lichen planus. They:

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    + Pityriasis lichenoides Mucha Habermann
    Lichen planus is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp, and nails. Lichen planus lesions are described using the six P’s (planar [flat-topped], purple, polygonal, pruritic, papules, plaques). Onset is usually acute, affecting the flexor surfaces of the wrists, forearms, and legs. The lesions are often covered by lacy, reticular, white lines known as Wickham striae. Classic cases of lichen planus may be diagnosed clinically, but a 4-mm punch biopsy is often helpful and is required for more atypical cases. High-potency topical corticosteroids are first-line therapy for all forms of lichen planus, including cutaneous, genital, and mucosal erosive lesions. In addition to clobetasol, topical tacrolimus appears to be an effective treatment for vulvovaginal lichen planus. Topical corticosteroids are also first-line therapy for mucosal erosive lichen planus. Systemic corticosteroids should be considered for severe, widespread lichen planus involving oral, cutaneous, or genital sites. Referral to a dermatologist for systemic therapy with acitretin (an expensive and toxic oral retinoid) or an oral immunosuppressant should be considered for patients with severe lichen planus that does not respond to topical treatment. Lichen planus may resolve spontaneously within one to two years, although recurrences are common. However, lichen planus on mucous membranes may be more persistent and resistant to treatment.
    Another case: Lichen planus, developed, HE 40x (3667)
    gold injections for the treatment of arthritis
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    Saliva sample collection and preparation

  8. Vitamine A zuur (tretinoïne) crème 1-2 dd. Dit middel heeft echter als nadeel irritatie.
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  10. Autoimmune Disease, Buccal Mucosa (Mouth Mucosa), Mucosa (Mucous Membranes)
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    ICD-10: L43ICD-9-CM: 697.0MeSH: D008010DiseasesDB: 7452
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    Histopathology[edit]
    palate
    Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014 Jan. 145 (1):45-56. [Medline].

  12. + Staphylococcal scalded skin syndrome
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    Localization
    Lear J. & English JSC. Erosive and generalized lichen planus responsive to azathioprine. Clinical and experimental dermatology. 1996; 21(1): 56-57.
    Most lichen planus is relatively mild. Affected individuals who do not have symptoms do not need treatment. Ultimately, there is no agreed-upon cure for this condition.
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  13. Prognosis
    HEPATITIS C VIRUS INFECTION AND ORAL LICHEN PLANUS
    Immunoblotting analysis of salivary proteins (complement C3c, fibrinogen fragment D, and cystatin SA) was performed in 3 pairs of age- and sex-matched oral lichen planus patients (LP1/2/3) and healthy control subjects (N1/2/3)
    May occur simultaneously with other subtypes
    7 Influenza A 37 Show member pathways 12.66 CASP3 CCL5 HSPA8 ICAM1 IL1A

  14. Lichen planus can be difficult to manage on the vulva and in the vagina, causing severe pain and sometimes leaving scars. Sexual dysfunction can become a long-term complication.
    Birthmarks
    Sources Sources for Oral Lichen Planus
    Center for Cerebrovascular Disorders

  15. + Verrucous affections caused by papillomavirus (HPV)
    The cause of lichen planus is unknown,[6][34][39] but it is not contagious and does not involve any known pathogen.[40] It is thought to be a T cell mediated autoimmune reaction (where the body’s immune system targets its own tissues).[37] This autoimmune process triggers apoptosis of the epithelial cells.[37] Several cytokines are involved in lichen planus, including tumor necrosis factor alpha, interferon gamma, interleukin-1 alpha, interleukin 6, and interleukin 8.[37] This autoimmune, T cell mediated, process is thought to be in response to some antigenic change in the oral mucosa, but a specific antigen has not been identified.[37]
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