lichen planus and lichen sclerosus | lichen planus specialist

Croatia – Hrvatska Subscribe to RSS Cytokeratin 9  Buccal mucosa, gingiva and tongue T. Vogt Lee JH, Kye KC, Seo EY, Lee K, Lee SK, Lim JS, et al. Expression of neutrophil gelatinase-associated lipocalin in calcium-induced keratinocyte differentiation. J Korean Med Sci. 2008;23(2):302–6.View ArticlePubMedPubMed CentralGoogle Scholar
Siribang-on Piboonniyom Khovidhunkit4Email author By Christian Nordqvist Oral Lichen Planus: Symptoms, Causes, and Treatments
19 FMA 8. Cooper SM, Arnold SJ, Robert L Barbieri, Callen J, Ofori AO. Vulvar Lichen Sclerosus. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. Last updated June 6, 2016. Accessed April 27, 2017.
Tue May 21, 20192019 AAOM Annual Meeting brand logo Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben. Im Falle von nicht mündigen Patienten liegt die Einwilligung eines Erziehungsberechtigten oder des gesetzlich bestellten Betreuers vor.
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The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. ( 29412487 )
All Proteins Resources… Ear, Nose and Throat Stress or anxiety Other Types 4 immune system MP:0005387 9.9 ICAM1 BAX IL1A CASP3 MMP1 TIMP2
Dialogues in Dermatology Level of Mucin 5B in unstimulated saliva. provides an image of oral lichen planus.
Suspected based on clinical presentation Submucosal papules, mucosal plaques, and erosions Lichen striatus on the leg 4. Freedberg IM, Fitzpatrick, TB. Fitzpatrick’s dermatology in general medicine. 5th ed. New York: McGraw-Hill, Health Professions Division, 1999. Variant Title: Dermatology in general medicine 2 v. (xxxi, 3002, 127 p.): ill.
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Fazel, Nasim. “Cutaneous Lichen Planus: A Systematic Review of Treatments.” J Dermatolog Treat, Early Online 1-4 (2014): 1471-1753. International Services
Patients with oral lichen planus may be at a slightly increased risk of developing oral cancer. Because of this increased risk, the American Academy of Dermatology recommends discontinuing the use of alcohol and tobacco products, which also increase the risk of oral cancer. Regular visits to the dermatologist – every six to twelve months – for oral cancer screening are also recommended.
Several systemic treatments are available for severe or recalcitrant cases of psoriasis. Which of the following requires that women who use it not be pregnant and that they should be warned against becoming pregnant for at least 2 yr after treatment ends?
Guide to Understanding Cancer Français Undiagnosed Rare Disease Patients Lichen planus: Symptoms Clobetasol (Temovate) Fluocinonide 2 inflammatory response GO:0006954 9.91 CCL5 CCR5 CXCR3 IL1A
Boyd, AS, Neldner, KH. “Lichen planus”. J Am Acad Dermatol. vol. 25. 1991. pp. 593-619. Condition
Acne treatment Thesaurus Sign in to make a comment + Warty dyskeratoma (solitary Darier’s disease) Travel Health Could This Red Bump Be Skin Cancer? No Results
Received + Bulla in diabetes It is not linked to nutrition. However, spicy foods, citrus juices, and tomato products may aggravate symptoms if there are open sores in the mouth.
Sex & Relationships Cutaneous lichen planus[edit]
Abnormal Uterine Bleeding Policies  – Elite gene  – Cancer Census gene in COSMIC Scoliosis [Skip to Content] Lacy, white, raised patches of tissues
Child Nutritional Needs If an internal link led you here, you may wish to change the link to point directly to the intended article.
Oral lichen planus lesions contain increased levels of the cytokine tumor necrosis factor (TNF)–alpha. [4, 5] Basal keratinocytes and T cells in the subepithelial infiltrate express TNF in situ. [6, 7] Keratinocytes and lymphocytes in cutaneous lichen planus express elevated levels of the p55 TNF receptor, TNF-RI. [8] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. [9] Serum and salivary TNF levels are elevated in oral lichen planus patients. [10, 11, 12, 13] TNF polymorphisms have been identified in patients with oral lichen planus, and they may contribute to the development of additional cutaneous lesions. [14] Oral lichen planus has been treated successfully with thalidomide, [15, 16] a drug known to suppress TNF production. [17, 18] Together, these data implicate TNF in the pathogenesis of oral lichen planus.
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For more information about clinical trials being conducted at the National Institutes of Health (NIH) Clinical Center in Bethesda, MD, contact the NIH Patient Recruiting Office: Reference Sequences
Hepatitis C screening in patients with oral lichen planus. ( 29971956 ) + Giant condylomata of Buschke-Loewenstein Fight Fleas and Ticks Haven’t registered yet?
Scleroderma is an autoimmune disorder of the connective tissues where the body’s im.. Jump up ^ Cheng, S; Kirtschig, G; Cooper, S; Thornhill, M; Leonardi-Bee, J; Murphy, R (Feb 15, 2012). “Interventions for erosive lichen planus affecting mucosal sites”. The Cochrane Database of Systematic Reviews. 2: CD008092. doi:10.1002/14651858.CD008092.pub2. PMID 22336835.
Vesicular lichen ruber (lichen planus pemphigoides): Lichen planus pemphigoides, HE 20x (4340) 2016 Fall Meeting Frontal Fibrosing Alopecia and Concomitant Lichen Planus Pigmentosus: A Case Series of Seven African American Women. ( 29601616 )
Diaper rash: How to treat Competing interests 4 heterophyiasis 10.7 CASP3 ICAM1
More Student Stories Resident Calendar Services and Centers Pimecrolimus 1% cream:
Over-the-counter pain medicine could help alleviate some symptoms of the pain, but it’s best to make an appointment with a dentist as soon as possible. Only then can you get a clear understanding of what’s going on and begin the treatment process.
Fellowship Study Resources References:[7] United Kingdom
Giving Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145(1):45–56.View ArticlePubMedGoogle Scholar
All Variation Resources… Received STUDENTSTORIES + Stucco keratosis Nature events Notes + Folliculotropic mycosis fungoides 24 GeneReviews
Asymptomatic (lacelike Wickham’s striae are the only finding) or
Definition and Epidemiology of Lichen Planus Conflict of Interest Policy + IgA pemphigus Sexually Transmitted Diseases (STDs) Oral lesions may be asymptomatic if reticular, but other patients with erythematous or ulcerative disease may complain of pain, difficulty eating, odynophagia, or bleeding gums (Figure 1). Involvement of the hair ranges from scarring alopecia of the scalp to nonscarring alopecia of the axilla and pubic hair (Figure 2). LP of the nails can cause formation of pterygium, onychorrhexis, and trachyonychia. It may also, rarely, be the cause of 20-nail dystrophy in children (Figure 3).
CME transcript Cutaneous lichen planus[edit] Reassurance (self-limited condition) Diagnosis and Treatment of Lichen Planus
Nature events Ethics approval and consent to participate It does not appear to be a hereditary condition. Cholesterol SEE WHAT’S NEW
Sources Summaries for Oral Lichen Planus How do animals protect their skin
Epidemiological evidences from more than 90 controlled studies worldwide strongly suggest that Hepatitis C Virus (HCV) may be an etiologic factor in OLP. The association seems to be prevalent in Southern Europe, Japan and USA. However, countries with highest prevalence of HCV report negative or nonsignificant associations suggesting that the LP–HCV association cannot be explained on the basis of high prevalence in population alone. In OLP, HCV replication has been reported in the epithelial cells from mucosa of LP lesions by reverse transcription/polymerase chain reaction or in-situ hybridization; also, HCV-specific CD4 and CD8 lymphocytes were reported in the subepithelial band. These probably suggest that HCV-specific T lymphocytes may play a role in the pathogenesis of OLP. The characteristic band like lymphocytic infiltrate might thus be directed toward HCV infected cells. Whether HCV infected patients have increased risk of developing OLP or patients with OLP have enhanced risk of developing HCV infection is yet to be answered. The putative pathogenetic link between OLP and HCV still remains controversial and needs a lot of prospective and interventional studies for a better understanding.[11]
+ Angulus infectiosus Lichen planus K’s Korner 1 extracellular space GO:0005615 9.86 CXCL9 DEFB4A ICAM1 IFNG IL4 KRT10 + Hidroacanthoma simplex + Crohn’s disease, skin changes Huidaandoeningen
International Services Gastroenterology and Hepatology Three to six weeks of oral prednisone therapy should be used to treat severe, widespread lichen planus (tapered course, 30 to 60 mg per day starting dose).
Did you know lichen planus affects not only skin but also oral mucosa? Disclosure forms provided by the authors are available with the full text of this article at
Narrow-band or broadband UV-B radiation [11, 6, 7]
Pharmacoepidemiology Overview Lopez-Jornet P, Cayuela CA, Tvarijonaviciute A, Parra-Perez F, Escribano D, Ceron J. Oral lichen planus: salival biomarkers cortisol, immunoglobulin a, adiponectin. J Oral Pathol Med. 2016;45(3):211–7.View ArticlePubMedGoogle Scholar
Systemic viral infection, such as hepatitis C (which might modify self-antigens on the surface of basal keratinocytes) Create a free personal account to access your subscriptions, sign up for alerts, and more
Lichenoid drug eruptions are reactions that may occur after exposure to various medications. These eruptions may exhibit a cutaneous and histologic appearance identical to that of idiopathic lichen planus and, thus, must be considered in every patient with lichen planus. While an exhaustive list of possible offending agents is quite long, the most common include gold, antimalarial agents, penicillamine, thiazide diuretics, beta blockers,7 nonsteroidal anti-inflammatory drugs, quinidine and angiotensin-converting enzyme inhibitors.8
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How do animals protect their skin 2015 Spring Meeting Lichen planus on the penis showing a lacy, white, annular pattern.
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Terms and conditions Nature Korea Pain 8 weeks Classically described as small, violaceous, polygonal, flat-topped papules and plaques on glabrous skin (Figure 4). A fine white, reticulated scale or punctae (Wickham’s striae) may be appreciated with dermoscopy. Commonly affected areas include the flexural surface of arms, legs, and wrists. The face and scalp are typically spared.
Frontal fibrosing alopecia is a form of lichen planopilaris that affects the anterior scalp, forehead and eyebrows.
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15 Replies to “lichen planus and lichen sclerosus | lichen planus specialist”

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    Some studies have revealed a prevalence of viral infections in oral lichen planus (eg, hepatitis C virus [HCV]). Some studies report human papillomavirus (HPV) types 6, 11, 16, or 18. [22, 23] Dysplastic oral lichen planus lesions had a higher prevalence of HPV-16 compared with nondysplastic oral lichen planus lesions. Some study findings suggest an association between oral lichen planus and chronic hepatic diseases such as HCV infection, autoimmune chronic active hepatitis, and primary biliary cirrhosis. [24, 25] This association probably reflects the geographic distribution of HCV disease and lichenoid reactions to various drug therapies (eg, interferon-alfa for HCV disease, penicillamine for primary biliary cirrhosis). Oral lichen planus is associated with HCV infection and liver disease in parts of Japan and southern Europe. An association between oral lichen planus and HCV infection has not been detected in British, French, German, Scandinavian, or American patients.
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  2. Topical calcineurin inhibitorsTacrolimus 0.03% or 0.1% ointment twice dailyPimecrolimus cream 1.0% twice daily    

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    Sources Sources for Oral Lichen Planus
    Medical Education and Training
    + Mucinous metaplasia

  4. Suspected based on clinical presentation
    5 peptide cross-linking GO:0018149 9.65 FLG IVL KRT10
    + Deposition of foreign material in the dermis
    20. Swift JC, Rees TD, Plemons JM, Hallmon WW, Wright JC. The Effectiveness of 1% Pimecrolimus cream in the treatment of oral erosive lichen planus. J Periodontol. 2005;76:627–35. [PubMed]
    13. Cevasco NC, Bergfeld WF, Remzi BK, de Knott HR. A case-series of 29 patients with lichen planopilaris: the Cleveland Clinic Foundation experience on evaluation, diagnosis, and treatment. J Am Acad Dermatol. 2007;57(1):47–53.
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    Observations  We performed a retrospective medical record review of 50 patients with histologically confirmed OLP. Patients were treated according to a therapeutic ladder of sequential treatments, beginning with topical corticosteroids and progressing through topical immunomodulators, systemic retinoids, methotrexate, and thalidomide. The best responses were observed in previously untreated patients. Most patients eventually achieved a substantial response with limited toxic effects.
    DISEASES inferred 15
    Skin cancer
    The exact causes of lichen planus are not yet understood.
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    Jump up ^ Cribier, B; Frances, C; Chosidow, O (December 1998). “Treatment of lichen planus. An evidence-based medicine analysis of efficacy”. Archives of Dermatology. 134 (12): 1521–30. doi:10.1001/archderm.134.12.1521. PMID 9875189.
    In cases where an allergy is suspected, a type of allergy test called patch testing may be helpful to identify the cause.

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    Jump up ^ James, William D.; Elston, Dirk M.; Berger, Timothy G. Andrews’ Diseases of the skin : clinical dermatology (11th ed.). London: Saunders/ Elsevier. p. 639. ISBN 1-4377-0314-3.
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  9. As an antibacterial agent, dapsone inhibits bacterial synthesis of dihydrofolic acid and hence is used in the treatment of leprosy. When used for the treatment of skin diseases, it probably acts as an anti-inflammatory agent by inhibiting the release of chemotactic factors for mast cells.[22] The most common untoward effect of dapsone is hemolysis of varying degree, which is dose related and develops in almost every individual administered 200–300 mg of oral dapsone daily. Glucose-6-phosphate dehydrogenase (G6PD) deficiency can increase the risk of hemolytic anemia or methemoglobinemia in patients receiving dapsone. Screening for G6PD deficiency is required before prescribing dapsone. Hypersensitivity reaction to dapsone called Dapsone reaction is frequent in patients receiving multiple drug therapy. The symptoms of rash, fever and jaundice generally occur within the first 6 weeks of therapy and can be ameliorated by corticosteroid therapy.[23]
    A topical corticosteroid is considered first-line therapy for patients with oral lichen planus.15 One controlled trial17 demonstrated the effectiveness of fluocinonide (Lidex) ointment applied to dried oral mucosa six times daily for nine weeks. The steroid, in an adhesive base, was prepared by the pharmacy, although Orabase has also been recommended as an occlusive vehicle.4 Other topical medications and systemic therapies have been used to treat patients with oral lichen planus15 that is corticosteroid-resistant. These therapies include topical cyclosporine, systemic corticosteroids, topical and systemic retinoids and oral PUVA.
    Lichen planus may occasionally present in the external auditory canal, according to this case series.
    Lopez-Jornet P, Cayuela CA, Tvarijonaviciute A, Parra-Perez F, Escribano D, Ceron J. Oral lichen planus: salival biomarkers cortisol, immunoglobulin a, adiponectin. J Oral Pathol Med. 2016;45(3):211–7.View ArticlePubMedGoogle Scholar
    Skin, hair, and nail care
    Vulvar lichen planus can undergo transformation to or may be associated with squamous cell carcinoma. Very rarely, even skin lesions can give rise to squamous cell cancer. The following factors increase the risk of transformation of lichen planus lesions to squamous cell carcinoma: smoking, heavy alcohol consumption, erosive or atrophic lesions, erythroplakic lesions, and mucosal involvement.
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    21. Radfar L, Wild RC, Suresh L. A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(2):187–193.
    Close-up view of lichen planus.
    Scully, C., & Carrozzo, M. (2008). Oral mucosal disease: Lichen planus. British Journal of Oral and Maxillofacial Surgery, 46(1), 15-21.
    Manousaridis I, Manousaridis K, Peitsch WK & Schneider S W. Individualizing treatment and choice of medication in lichen planus: a step by step approach. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2013;11(10): 981-991.
    A: Often the reticular form of oral lichen planus does not require any treatment, except periodic observation by a health care professional. The erosive and ulcerative forms can usually be controlled with the use of topical corticosteroids. In some cases, systemic steriods or other medicines may be prescribed by your doctor.
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    Table 4

  11. OLP (n = 5)
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    10 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
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    One study12 reported that, in Indianapolis, a region with a low endemic prevalence of HCV, tests for HCV antibody were positive in 3.5 percent of patients with lichen planus. However, only patients with abnormal liver function tests were screened. Two studies of patients with lichen planus that did not exclude patients with normal liver function reported a positive HCV antibody in 23 percent of patients tested in Miami13 and 60 percent of patients tested in a region of Japan with a high endemic HCV prevalence.14

  12. Sources Expression for Lichen Planus
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    ^ Jump up to: a b Freedberg, Irwin M., ed. (2003). Fitzpatrick’s dermatology in general medicine (6th ed.). New York, NY: McGraw-Hill. p. 473. ISBN 0-07-138076-0.
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    Psoriasis is a common chronic skin condition. It causes a rash that is raised with red marks and flaky…
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