autoimmune skin disease lichen planus | lichen planus throat

Vulval lichen planus Head Lice infestation Could Cause Iron Deficiency Anemia There are also variations of the condition more common in the Middle East, Asia, Africa, and Latin America.
15 DISEASES Shop Children’s Health Popovska M, Grchevska L, Atanasovska-Stojanovska A, Kapushevska B, Muratovska I, Minovska A, et al. Role of humoral mechanisms in etiology of lichen planus. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2014;35(3):185–94.Google Scholar
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Editor’s Collections Allergic Skin Disorders [Lichen ruber planus : Better understanding, better treatment!] Lichen planus has a unique microscopic appearance that is similar between cutaneous, mucosal and oral. A Periodic acid-Schiff stain of the biopsy may be used to visualise the specimen. Histological features seen include:[44]
Gold Fazel, Nasim. “Cutaneous Lichen Planus: A Systematic Review of Treatments.” J Dermatolog Treat, Early Online 1-4 (2014): 1471-1753. Pityriasis rosea
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+ Erythema dyschromicum perstans Ayan Kusari, M.A. 9. Sulle papule del lichen ruber planus appare, generalmente, un reticolo biancastro: è un segno tipico della dermatosi, che permette il riconoscimento immediato. Le papule possono rimanere isolate oppure raggrupparsi formando veri e propri ammassi abnormi. Il problema principale, che ostacola la diagnosi, è dato dal grattamento consistente generato dalle papule: il soggetto affetto, attraverso lo strofinio, toglie la pellicola superficiale della lesione, impedendo il riconoscimento clinico.
Free toolbar & extensions Sodium dodecyl sulfate polyacrylamide gel Gum Disease Treatment Therapy – lichen planus annularis + Lymphoepithelioma-like carcinoma of the skin There are many different skin disorders. Some skin disorders, like contact dermatitis, are temporary and relatively minor, while others, like…
Try not to scratch. Covering the rash with a bandage can help. Last updated Wed 20 December 2017 Last updated Wed 20 Dec 2017 + Stevens-Johnson syndrome
The Page You Have Requested Does Not Exist Bad Breath Patient Care What causes itchy fingers? There are many reasons for itchy fingers, including allergic reactions and skin conditions. Depending on the cause, the itchiness may appear alongside redness, scaly skin, or small blisters. A person can treat itching fingers with various creams or tablets. Learn more about causes and getting rid of itchiness here. Read now
For Researchers Physics Social Media Hub Risk factors Isolated oral involvement occurs in 15% to 35% of cases, but 65% of all patients have some oral involvement; 25% of women with oral LP will also have vulvovaginal involvement, thus the need to specifically inquire about genital involvement. Nail involvement is reported in 1% to 10% of cases; 80% of lichen planopilaris occurs in women. Trauma (Koebner phenomenon) is a known risk factor for development of LP.
+ Osteoarthritis, Heberden nodes MW While this “classic” form of cutaneous lichen planus is the most common, other variants do exist and exhibit various morphologies. Patients with hypertrophic lichen planus present with thick hyperkeratotic plaques, commonly found on the anterior surface of the legs (Figure 4). In vesiculobullous lichen planus, patients exhibit blisters within the plaques, while the actinic type of lichen planus occurs on sun-exposed areas of skin.
Copyright © 2015 The Authors. Published by Elsevier Inc. Another case: Lichen ruber planus, HE 20x (156) Lichen ruber planus, HE 40x (157) Audio Interviews 10
4.74 Lichen planus pemphigoides. ( 29465781 )
+ Bronchogenic cyst JAMA Dermatology Symptom Checker Decorso della malattia articles In patients who are suffering from painful erosive OLP and are unresponsive to even topical superpotent corticosteroids, surgical management using cryosurgery and different types of laser have also been tried. A 980-nm Diode laser,[30] CO2 laser evaporation,[31] biostimulation with a pulsed diode laser using 904-nm pulsed infrared rays[32] and low-dose excimer 308-nm laser with UV-B rays have been tried.[28] All types of laser destroy the superficial epithelium containing the target keratinocytes by protein denaturation. A deeper penetrating beam like the diode laser destroys the underlying connective tissue with the inflammatory component along the epithelium. The few studies documented show a lot of promise, but their effectiveness is yet to be proven.
Isolated oral involvement occurs in 15% to 35% of cases, but 65% of all patients have some oral involvement; 25% of women with oral LP will also have vulvovaginal involvement, thus the need to specifically inquire about genital involvement. Nail involvement is reported in 1% to 10% of cases; 80% of lichen planopilaris occurs in women. Trauma (Koebner phenomenon) is a known risk factor for development of LP.
DERMATOLOGY ADVISOR FACEBOOK 20. Cottoni F, Ena P, Tedde G, Montesu MA. Lichen planus in children: a case report. Paediat Dermatol. 1993;10(2):132-135.
22916-47-8 4189 Interventional clinical trials: (show all 48) There are four forms of oral lichen planus: reticular, atrophic, bullous, and erosive.6 The reticular form is most common and manifests as bilateral, asymptomatic Wickham striae on the oral mucosa (Figure 8) or other parts of the mouth, such as the gingiva, tongue, palate, and lips (Figure 95). The atrophic form causes atrophic changes with erythema of the oral mucosa. The bullous form manifests as fluid-filled vesicles. The erosive form leads to ulcerated, painful, erythematous areas that may contract secondary infection, such as candidiasis. These ulcerated areas may have Wickham striae and occur in one or multiple sites of the mouth. Erosive lichen planus of the gums resembles desquamative gingivitis. Malignant transformation has been reported in men with oral erosive lichen planus lesions.10
Drugs for Oral Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB): (show top 50) (show all 112) 10 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
Your doctor may also take a swab culture from the affected area, which can look for secondary infections.
That’s one reason for the popularity of Texas A&M University College of Dentistry’s online International Oral Lichen Planus Support Group, a web-based support group that brings together sufferers from throughout the world.  The on-line organization serves as a resource for patients, family members and practitioners.
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Treatment for Lichen Planus + Skin tumors Hypertrophic plaques Jump up ^ Freedberg, Irwin M., ed. (2003). Fitzpatrick’s dermatology in general medicine (6th ed.). New York, NY: McGraw-Hill. p. 468. ISBN 0-07-138076-0.
R/ EMLA crème, 4-6 dd aanstippen met wattenstaafje, of 30 minuten voor het eten aanbrengen.
News & Twitter Facebook Linked In Email Asymptomatic LP does not require treatment. Drugs suspected of triggering LP should be stopped; it can takes weeks to months after the offending drug has been stopped for the lesions to resolve.
General Dermatology Oral Lichen Planus. New Zealand Dermatologic Soceity, inc.. Ocotber 2010; Accessed 7/20/2011.
Summer Programs Research Overview All How To ENGLISH Lichen planus. Merck Manual Professional Version. Accessed Feb. 5, 2016.
our Machines Lopez-Jornet P, Cayuela CA, Tvarijonaviciute A, Parra-Perez F, Escribano D, Ceron J. Oral lichen planus: salival biomarkers cortisol, immunoglobulin a, adiponectin. J Oral Pathol Med. 2016;45(3):211–7.View ArticlePubMedGoogle Scholar
Folliculitis IMURAN + Intravascular T lymphoma February 23, 2012 Give Response per Course as a Function of Treatment Type + Acute neonatal lupus erythematodes
Did you know some cases of lichen planus may be reaction to particular medicine?
Last update January 23, 2018 + Twenty nail dystrophy Mouth ulcers Kumaraswamy KL, Vidhya M, Rao PK, Mukunda A. Oral biopsy: oral pathologist’s perspective. J Cancer Res Ther. 2012 Apr-Jun. 8 (2):192-8. [Medline].
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Lichen planus may occasionally present in the external auditory canal, according to this case series. Last updated: 7/20/2011 A MEDICAL EDUCATION BLOG It has been my good fortune to be able to report this extremely rare and interesting case. The rarity of the disease and the multiform character of the lesions are of sufficient interest in themselves. In addition, the case serves as a corroboration to one of the conclusions reached in a previous article,1 namely, that lichen planus and lichen acuminatus are closely related to one another. One of the arguments on which this conclusion is based is the comparative frequency with which the two diseases occur at the same time in the same person.
Create a book + Cherry hemangioma 58.4 Featured content Most people can manage typical, mild cases of lichen planus at home, without medical care. If the condition causes pain or significant itching, you may need prescription drugs.
SOURCES: The following may be noted in the patient history: The differential diagnosis of hair and nail LP include the following entities: 1) discoid lupus erythematosus (distinguished by scarring discoid plaques, sun-exposed rash and biopsy); 2) onychomycosis (positive potassium hydroxide test or fungal culture); 3) psoriasis (nail pitting, oil staining, onycholysis, skin involvement).
Epidemiological evidences from more than 90 controlled studies worldwide strongly suggest that Hepatitis C Virus (HCV) may be an etiologic factor in OLP. The association seems to be prevalent in Southern Europe, Japan and USA. However, countries with highest prevalence of HCV report negative or nonsignificant associations suggesting that the LP–HCV association cannot be explained on the basis of high prevalence in population alone. In OLP, HCV replication has been reported in the epithelial cells from mucosa of LP lesions by reverse transcription/polymerase chain reaction or in-situ hybridization; also, HCV-specific CD4 and CD8 lymphocytes were reported in the subepithelial band. These probably suggest that HCV-specific T lymphocytes may play a role in the pathogenesis of OLP. The characteristic band like lymphocytic infiltrate might thus be directed toward HCV infected cells. Whether HCV infected patients have increased risk of developing OLP or patients with OLP have enhanced risk of developing HCV infection is yet to be answered. The putative pathogenetic link between OLP and HCV still remains controversial and needs a lot of prospective and interventional studies for a better understanding.[11]
– lichen planus mucosae (mondholte, lippen, vagina, penis, anaal en perianaal, oesofagus, neusslijmvlies)
Quizzes Other medications Erosive oral lesions and widespread itchy skin lesions often require the use of a systemic corticosteroid (e.g., oral prednisone). Unfortunately, skin lesions may return after systemic prednisone has been discontinued. In this case, continued low dosage of a systemic corticosteroid may be instituted.
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How to get rid of a blind pimple Leave feedback Topical calcineurin inhibitorsTacrolimus 0.03% or 0.1% ointment twice dailyPimicrolimus 1.0% cream once or twice daily Biopsy any suspicious lesions (ulcers, morphologically unique areas) to rule out malignant transformation    
Mucous membranes: Lichen planus of the mucous membranes of the mouth and genitals is common. It appears as a white, lacy rash on the inside of the cheeks or the vagina and may not cause symptoms. The oral rash often occurs prior to any skin involvement. More troublesome, although rare, is erosive lichen planus, which can be quite sore and uncomfortable. This erosive form typically causes the patient to complain of the shallow and often quite painful, recurrent ulcers in the mouth or genitals. Lichen planus of the female genitalia can involve the external vulvar mucosa and the internal vaginal mucosa. There is an association with cancer in these areas, so both the oral and vaginal tissues need to monitored by a medical professional.
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gi|532,598 History R/ Elidel (pimecrolimus) crème 1%, tube à 30 g. Lichen verrucosus (hypertrophicus) 20/4 Histopathology of LP is distinctive and can aid in diagnosis. Mature lesions classically display destruction of the basal layer, irregular acanthosis in a “sawtooth” pattern, lichenoid lymphocytic infiltrate, and Civatte bodies, which represent collections of necrotic keratinocytes (Figure 7). Wickham’s striae are thought to represent an increased granular cell layer. Direct immunofluorescence (DIF) shows shaggy fibrinogen and IgM deposits along the basement membrane zone and Civatte bodies, respectively. DIF may be particularly helpful in distinguishing LP from lupus or immunobullous disorders.
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10 Replies to “autoimmune skin disease lichen planus | lichen planus throat”

  1. References:[7][8][9][2][3][10][11][12][13][14]
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    Steroid creams or ointments can be very effective in reducing inflammation and redness. The medication is applied to the itchy spots. Treatment should stop when the spots change color to brown or gray.
    Lichen planus was first described in the literature by Eramus Wilson in 18692 as predominately a disease of the middle-aged or older. There is limited literature available reporting the occurrences of oral lichen planus in children.4,5,7,8,15-20 Childhood lichen planus has been documented as a complication of hepatitis B virus (HPV) vaccination, where the recombinant proteins of the HBV vaccine—specifically the viral S epitope—may trigger a cell-mediated autoimmune response targeted at keratinocytes, giving rise to a lichenoid reaction.21,22 It is also found in association with predisposing conditions such as graft-versus-host disease (GVHD) and chronic active hepatitis C. Cottoni20 reported oral lichen planus involvement in one patient affected by autoimmune chronic active hepatitis, and Agrawal22 reported oral lesions in one patient after HBV vaccination.
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    Cyclosporine: Start at 1mg/kg and increase to a max of 4.5mg/kg divided twice daily.  Should not be used more than 12 months due to renal toxicity.    
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    Follicular (lichen planopilaris): Multiple, small, spiny lesions around hair follicles.
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    Q: What treatment is necessary for oral lichen planus?

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  4. If you suffer from a condition that compromises your immune system or you’re taking certain medications, your risk of developing oral lichen planus may be increased. However, at this point in time medical experts are still unsure of the exact cause.
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  5. Sometimes form painful ulcers
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    In medicine, a small, abnormal patch of tissue on a body part or an organ. Plaques may also be a build-up of substances from a fluid, such as cholesterol in the blood vessels.
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  6. Skin, hair, and nail care
    Hydroxychloroquine 50 to 100 mg twice once to twice daily      
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    Reticular oral lichen planus on the buccal mucosa on the left side.
    Vesicular and bullous lichen planus

  7. 5. NVDV Richtlijn lichen planus. PDF
    lesions that develop and spread over the body over the course of several weeks or a few months
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    Mucosal forms are those affecting the lining of the gastrointestinal tract (mouth, pharynx, esophagus, stomach, anus), larynx, and other mucosal surfaces including the genitals, peritoneum, ears, nose, bladder and conjunctiva of the eyes.[9][10][11]
    An autoimmune reaction, meaning the body’s own defense system, the immune system, attacks your mouth and skin cells by mistake
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    These are the most commonly used group of drugs for the treatment of OLP.[14] The rationale behind their usage is their ability to modulate inflammation and immune response. They act by reducing the lymphocytic exudate and stabilizing the lysosomal membrane.[15] Topical midpotency corticosteroids such as triamcinolone acetonide, high-potent fluorinated corticosteroids such as fluocinonide acetonide, disodium betamethasone phosphate, and more recently, superpotent halogenated corticosteroids such as clobetasol are used based on the severity of the lesion. The greatest disadvantage in using topical corticosteroids is their lack of adherence to the mucosa for a sufficient length of time. Although trials were done using topical steroids along with adhesive base, no study shows their superiority when compared to steroids without the base (carboxymethyl cellulose).[16] However, the same study also recommends the usage of adhesive paste used for dentures, which contains only inactive ingredients as a vehicle to carry the topical application. This has shown excellent bioadhesive properties, due to its high molecular weight (above 100,000) and the flexibility of the polymeric chain. Small and accessible erosive lesions located on the gingiva and palate can be treated by the use of an adherent paste in a made-to-measure tray (custom tray), which allows for accurate control over the contact time and ensures that the entire lesional surface is exposed to the drugs.[17] Patients with widespread forms of OLP are prescribed high-potent and superpotent corticosteroids mouthwashes and intralesional injections. Long-term use of topical steroid can lead to the development of secondary candidiasis which necessitates antifungal therapy.[15] The potential tachyphylaxis and adrenal insufficiency is high when using superpotent steroids like clobetaso l, especially when used for a longer period of time. Systemic corticosteroids are reserved for recalcitrant erosive or erythematous LP where topical approaches have failed. Systemic prednisolone is the drug of choice, but should be used at the lowest possible dosage for the shortest duration (40–80 mg for 5–7 days).[14]
    Torti DC, Jorizzo JL, McCarty MA. Oral Lichen PlanusA Case Series With Emphasis on Therapy. Arch Dermatol. 2007;143(4):511–515. doi:10.1001/archderm.143.4.511
    Lichen planus (LP) is thought to be an autoimmune disorder in patients with a genetic predisposition but may be caused by drugs or be associated with disorders such as hepatitis C.

  9. Li P, Gao XH, Chen HD, Zhang Y, Wang Y, Wang H, et al. Localization of haptoglobin in normal human skin and some skin diseases. Int J Dermatol. 2005;44(4):280–4.View ArticlePubMedGoogle Scholar
    – lichen planus bij kinderen: is heel zeldzaam en wordt vaak niet herkend; verder identiek aan lichen planus bij volwassenen
    Dalmau J, Puig L, Roé E, Peramiquel L, Campos M, Alomar A. Successful treatment of oral erosive lichen planus with mycophenolate mofetil. J Eur Acad Dermatol Venereol. 2007 Feb. 21 (2):259-60. [Medline].
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    Lichen planus may spontaneously resolve.
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    Jump up ^ Antiga, E.; Caproni, M.; Parodi, A.; Cianchini, G.; Fabbri, P. (2014-12-01). “Treatment of cutaneous lichen planus: an evidence based analysis of efficacy by the Italian Group for Cutaneous Immunopathology”. Giornale Italiano Di Dermatologia E Venereologia: Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia. 149 (6): 719–26. ISSN 0392-0488. PMID 25664824.
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    Histologic view of cutaneous lichen planus demonstrating a “saw-toothed” appearance of the epidermis, a lichenoid infiltrate, and pigment incontinence.
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